منابع مشابه
Drug therapy in the elderly.
Drug dosage in the elderly requires an understanding of the age-dependent changes in drug disposition and sensitivity. The most important pharmacokinetic alteration is a decline in renal function, the elderly should therefore be treated as renally insufficient patients. Metabolic clearance is primarily reduced with drugs that display high hepatic extraction, whereas the metabolism of drugs with...
متن کاملDrug therapy in the elderly.
Special considerations must be invoked when prescribing medications for the elderly. Although basic absorption is unchanged, many elderly patients are prone to chronic diarrhea or constipation, either of which may alter intestinal contact time and, thus, absorption. Concurrent use of such drugs as antacids or iron preparations may affect the availability of some compounds for absorption. The pr...
متن کاملDrug therapy in elderly.
Population aging is considered as the most serious problem in developed countries and is going to be a threat for developing countries. Aging is associated with various physiological changes and multiple diseases like diabetes, hypertension, arthritis etc. which alter the pharmacological response to a drug. Moreover, elderly people are more sensitive to frequently used drugs like NSAIDs, benzod...
متن کاملCardiovascular drug therapy in the elderly.
Pharmacokinetic considerations in the elderly include absorption, bioavailablility, drug distribution, half-life, drug metabolism, and drug excretion. There are numerous physiologic changes with aging that affect pharmacodynamics with alterations in end-organ responsiveness. This article discusses use of cardiovascular drugs in the elderly including digoxin, diuretics, beta-adrenergic blockers,...
متن کاملCardiac drug therapy—considerations in the elderly
Elderly individuals constitute a majority of patients encountered in current cardiovascular clinical practice. Management of these patients is a clinical challenge owing to a multitude of factors. Although medications such as statins have been shown to reduce cardiovascular mortality in the general population, evidence supporting the use of these drugs in patients greater than 75 years of age i...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1998
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(97)91654-x